- Colombia are the slight favorites for this game at 2.15, with Ghana 3.65 and the draw 3.2.
- Colombia have won four and drawn one of their last five games.
- Ghana have won one, drawn two and lost two of their last five.
South Americans are on the march
Colombia will be the more likely winners of Saturday's opening knockout-stage clash with Ghana at Kansas City Stadium in what should be a hard-fought and competitive game, according to our Colombia vs Ghana prediction.
Nestor Lorenzo's men are on a hot streak with four wins and a draw from their last five and come into this with a lot more momentum than Ghana, whose form has been mixed at best.
Los Cafeteros have been in excellent form across all competitions with six wins, two draws and two defeats in their last 10 - a sequence that suggests they can edge their opponents in what should be a close game in this Colombia vs Ghana preview.
Ghana have enough to keep it close
Colombia's last three FIFA World Cup games in Group K were a 3-1 win at Uzbekistan, a 1-0 victory over DR Congo and a 0-0 away draw with Portugal, while Ghana's results in Group L were a 1-0 victory over Panama, a 0-0 away against England and a 2-1 loss to Croatia.
The South Americans will face Ghana like they did Portugal, who are a much better team than the African side, while Carlos Queiroz's men will set up to be compact, to win the second balls and be dangerous when the counters come their way on the break or via set plays.
Colombia's best chance of beating Ghana is to ratchet up the pressure and make them play at their pace, but the Black Stars can always get a goal, so our preference is for a Colombia win and an under 2.5 goals bet, which is the best way to play the odds for this match. BTTS-No is a shade of odds against, but could be worth a play at 1.62, in what could be a tense affair, and Colombia vs Ghana betting tips lean toward a narrow South American success.
Colombia vs Ghana prediction points to a tight contest, but the South Americans should have enough to edge it.